#6129 INTRADIALYTIC PARENTERAL NUTRITION IMPROVES PROTEIN STORES IN CHRONIC HEMODIALYSIS PATIENTS

Abstract Background and Aims Intradialytic parenteral nutrition (IDPN) is a form of supplemental used to treat patients with malnutrition who receive hemodialysis (HD) in which the oral feeding not enough cover basic caloric needs. Although this technique could improve biochemical markers nutrition, information regarding its effect on body deposits lacking. We evaluated IDPN composition parameters nutritional status prevalent HD patients. Method Retrospective observational study that included all received NPID for more than 3 months at our Center from January 2018 December 2022. All concentrated 3-in-1 formula consisting glucose solution, lipid emulsion an amino acid solution without electrolytes (OLIMEL N9®, Baxter). was infused constant rate exceeding 300 ml/hour, via venous drip chamber monitor using infusion pump. Changes lean tissue mass (LTM), intracellular water (ICW), cell (BCM) assessed by multifrequency bioimpedance spectroscopy (BIS) baseline 3, 6, 9 12 (primary outcomes) other anthropometric (secondary were assess NPID. Results Seventeen (women: 9, 53%; mean age: 68±15 y). After initiation, gradual improvement LTM, ICW BCM observed, reaching statistical significance Month 12. fat inversely mirrored those LTM (Table 1). Albumin levels normalized protein appearance increased, significant reduction high-sensitive C-reactive extracellular/intracellular ratio month Conclusion 1-year associated increased muscle mass, supporting hypothesis supplement benefit revert protein-energy wasting